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Iodine deficiency causes thyroid disease (3,4)

One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes ( -helix formation at the N-terminus

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Glutathione is known as a powerful antioxidant, which is naturally produced in the body

10.1016/j.mehy.2017.02.017 Med Hypotheses